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18F-FPABZA material

Keywords: synthetic equipment disposable consumables

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18F-FPABZA material

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18F-FPABZA material

1. Drug name (generic name, chemical name, English name, Pinyin, if there is a customized name, the basis of naming should be explained)

common name:

Fluorine [18F]-FPABZA

chemical name:

N-(4-((2-(Diethylamino)ethyl)carbamoyl)-3-methoxyphenyl)-5-fluoropicolinamide

2. Chemical structure, molecular weight and molecular formula of the drug

chemical constitution:

Molecular weight: 388.44

Molecular formula: C₂₀H₂₆FN₃O₃

3. Basis of the topic (literature on the development and application of this product at home and abroad)

18F-FPABZA is a novel melanin-targeted PET probe designed to enhance the early detection of melanoma. Melanoma is a highly aggressive form of skin cancer, and traditional PET probes (such as 18F-FDG) lack specificity, making it difficult to accurately detect melanoma in its early stages. Therefore, developing a specifically targeted PET probe for melanin has become a key focus of research.

As a new type of melanin-targeted PET probe, 18F-FPABZA has shown good potential in the early detection of melanoma. However, it has not been used in clinical practice at home and abroad, and further clinical trials are needed to verify its safety and effectiveness.

4. Research methods, experimental conditions and other data of target organs and whole body imaging or simulated clinical function measurement tests of experimental animals, and imaging or functional measurement results observed at various phases of the test

I. Whole body imaging and delayed imaging of experimental animals

1. Materials and methods

1.1 Experimental animals

The experimental animal was a mouse, which was provided by Hangzhou Medical College. The weight of the mouse was about 200g and it was male. After injection of the drug and anesthesia, PET scan was performed to collect images and obtain the distribution map of the drug in the body. After imaging, the experimental animal gradually woke up and returned to normal, with good diet, urine and feces, and mental state.

The figure below shows the 30min imaging image

7. Instructions for drugs

[Drug Name]

Generic name: Fluor [18F]-FPABZA

N-(4-((2-(Diethylamino)ethyl)carbamoyl)-3-methoxyphenyl)-5-fluoropicolinamide

Pinyin: Fu[18]-FPABZA

[element]

Main ingredients: fluorobetaplan-18F, a new melanin targeting, its structural formula is:

[Properties] A clear solution from colorless to pale yellow

[Indications] Melanoma

[18F-FPABZA PET/C brain imaging process]

1. Preparations before inspection

Patient prepared

Fasting for at least 6 hours (water is allowed), avoid strenuous exercise and high sugar diet, to reduce the background metabolic interference;

Remove metal accessories (such as hair clips, dentures, etc.) from the head and change into a check suit with no metal buttons;

Diabetic patients need to adjust their blood glucose to less than 11 mmol/L in advance;

Imaging agent preparation and injection

Intravenous injection of 18F-FPABZA (the dose is calculated according to body weight, usually 5-10 mCi), and remain in a state of rest and closed eyes after injection to avoid interference of brain activity with imaging;

2. Absorption and distribution of imaging agents

Waiting period: 45-60 minutes of rest after injection to ensure that 18F-FPABZA fully penetrates the blood-brain barrier and binds to the target (such as β-amyloid or other specific molecules);

Urination and drinking water: the bladder should be emptied before examination, and appropriate amount of water should be drunk to reduce the impact of urinary system radiation on images;

PET/CT acquisition: The scan must be performed exactly 50 minutes after the injection of the contrast agent. The static scan duration is 50 minutes post-injection, with a collection time of 20 minutes. Dynamic acquisition spans from 0 to 60 minutes. CT and PET acquisition parameters and reconstruction methods should align with those used for brain 18F-FDG imaging. Strict control over the injection and scan times is required, and these times must be meticulously recorded.

Image interpretation and analysis: timely interpretation of images.

Report: Report in time.

Follow-up: 18F-FPABZA and 18F-FDG brain imaging should be spaced at least 10 half-lives (or 20 hours).

This product is only for use in medical units with a radioactive Drug Use License.

[untoward effect]

Not yet found.

[taboo]

Not yet found.

[matters need attention]

If the product changes color or becomes cloudy, stop using it.

This product is only for use in medical units with a radioactive Drug Use License.

[Pregnant and lactating women]